scientific publications

multiple sclerosis

Antonio M, Patrizia F, Ilaria I, Paolo F, A rational approach on the use of sex steroids in multiple sclerosis: Recent Pat CNS Drug Discov. 2008 Jan; 3(1):34-9.

Sicotte N L, Liva SM, Klutch R, Pfeiffer P, Bouvier S, Odesa S, Wu TC, and Voskuhl RR, 2002, Treatment of multiple sclerosis with the pregnancy hormone estriol: Ann.Neurol., v. 52, no. 4, p. 421-428.

Soldan, SS, AIvarez Retuerto, AI, Sicotte, NL and Voskuhl, RR, 2003, Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol: J.Immunol., v. 171, no.11, p. 6267-6274.

Zang YC, Halder JB, Hong J, Rivera VM, Zhang JZ., Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B., J Neuroimmunol. 2002 Mar;124(1-2):106-14.

Palaszynski KM, Liu H, Loo KK, Voskuhl RR., Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis., J Neuroimmunol. 2004 Apr;149(1-2):84-9.

Liu HB, Loo KK, Palaszynski K, Ashouri J, Lubahn DB, Voskuhl RR., Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease., J Immunol. 2003 Dec 15;171(12):6936-40.

Voskuhl RR. Gender issues and multiple sclerosis., Curr Neurol Neurosci Rep. 2002 May;2(3):277-86.

Voskuhl RR, Palaszynski K., Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis., Neuroscientist. 2001 Jun;7(3):258-70.

Kim S, Liva SM, Dalal MA, Verity MA, Voskuhl RR., Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis., Neurology. 1999 Apr 12;52(6):1230-8.


Stoll AL., Fibromyalgia symptoms relieved by flupirtine: an open-label case series. Psychosomatics. 2000 Jul-Aug;41(4):371-2.

Sättler MB, Williams SK, Neusch C, Otto M, Pehlke JR, Bähr M, Diem R. Flupirtine as Neuroprotective Add-On Therapy in Autoimmune Optic Neuritis. Am J Pathol. 2008 Oct 2.

Fawcett RJ, Osborne NN. Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ. Brain Res Bull. 2007 Jul 12;73(4-6):278-88. Epub 2007 May 21.

Müller-Schwefe GH, Uberall MA. Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain. Results of a standardized therapeutic evaluation applying objective methods for measuring pain pressure threshold, pain pressure tolerance and muscle tension, MMW Fortschr Med. 2008 Jan 17;149 Suppl 4:153-61.

Kamchatnov PR, Btysheva TT, Ganzhula PA, Gaponova OV, Zhuravleva EIu, Ismailov AM, Kostenko EV, Bo?ko AN. The use of katadolon (flupirtine) in patients with spondylogenic dorsalgia Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106(11):46-8.

Dörr J, Roth K, Zurbuchen U, Deisz R, Bechmann I, Lehmann TN, Meier S, Nitsch R, Zipp F. Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate. J Neuroimmunol. 2005 Oct;167(1-2):204-9.

Nash MS, Wood JP, Melena J, Osborne NN. Flupirtine ameliorates ischaemic-like death of rat retinal ganglion cells by preventing calcium influx. Brain Res. 2000 Feb 21;856(1-2):236-9.

ALS (amyotrophic lateral sclerosis, also known as lou gehrig’s disease)

Phoenix Neurological Associates, LTD , Sponsor; The Ethnomedicine Institute, Collaborator; Safety Study of High Doses of Zinc in ALS Patients, (a service of the U.S. National Institutes of Health), URL: clinicaltrials.

Kuehn, BM, Environmental Neurotoxin May Pose Health Threat,JAMA, Vol. 293, No. 20, May 25, 2005, p. 2460-2462.

Pain, S, Bat out of Hell, New Scientist, Issue no. 2429, January 10, 2004, p. 50-51.

Milius, S, Mechanism Suggested for Guam Illness, Science News, Vol. 166, No. 7, Aug. 14, 2004, p. 110.

Allen, TJ, Did a lake trigger a deadly disease?, The Boston Globe, September 14, 2009.

Hampton, T, Food Chain of Evidence Points to Brain Toxin, JAMA, Vol. 290, No. 21, December 3, 2003, p. 2788-2789.

Minkel, JR, Choi, CQ, News Scan Briefs: Brain-Destroying Algae?, Scientific American, June 2005, p. 34.

Alzheimer’s disease

Brewer GJ, Kanzer SH, Zimmerman EA, Molho ES, Celmins DF, Heckman SM, Dick R., Subclincial zinc deficiency in Alzheimer's diesease and Parkinson's disease. Am J Alzheimers Dis Other Dem., 2010 Nov;25(7):572-5.

Brewer GJ, Kanzer SK, Zimmerman EA, Celmins DF, Heckman SM, Dick R., Copper and Ceruloplasmin Abnormalities in Alzheimer's Disease. Am J Alzheimers Dis Other Dem., 2010 Sept; 25:490-497.

Brewer GJ, Copper toxicity in the general population (editorial). Clin Neurophysiol., 2010 Apr;121(4):459-60.

Brewer GJ, Risks of Copper and Iron Toxicity during Aging in Humans. Chem. Res. Toxicol., 2010;(2):319–326.

Brewer GJ, The Risks of Copper Toxicity Contributing to Cognitive Decline in the Aging Population and to Alzheimer's Disease. Journal of the American College of Nutrition., 2009 Jun;28(3):238-242.

common cold (oral zinc lozenge)

Prasad AS, Beck FWJ, Bao B, Snell DC, Fitzgerald JT, Duration and Severity of Symptoms and Levels of Plasma Interleukin-1 Receptor Antagonist, Soluble Tumor Necrosis Factor Receptor, and Adhesion Molecules in Patients with Common Cold Treated with Zinc Acetate, JID, 2008; 197:795-802.

Prasad AS, Fitzgerald JT, Bao B, Beck FWJ, Chandrasekar PH, Duration of Symptoms and Plasma Cytokine Levels in Patients with the Common Cold Treated with Zinc Acetate, Ann Intern Med, 2000; 133:245-252.

infection prevention in the elderly (zinc)

Prasad AS, Beck FWJ, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJ, Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress, Am J Clin Nutr, 85; 837-44 (2007).